New medicines are developed for people with Leukemia

Health Net: Team of researchers in England has just discovered a medicine that could treat leukemia or blood cancer.

Researchers from the University of Cambridge, in England, announced the formation of a new drug that can be used to treat one of the most common forms of Leukemia, mixed lineage leukemia (MLL), which is caused by leukemia fusion hereditary factors. This condition often affects infants.

In a paper published in the scientific journal Nature October 2 edition. The team said that the Leukemia medicines shows promise something when conducted trials and tests they plan to expand them further.

More than 10 percent of all adults diagnosed with leukemia caused by MLL. However, more severe in children, where 80 percent of all cases of acute leukemia is believed to be due to the MLL. Standard treatment often fails to cure such patients. It is quoted by Softpedia on Tuesday October 4, 2011.

Even if they managed to do the healing, then the time will not be long because this disease has a bad habit to come back. This happens because the form of blood cancer also has a genetic basis.

The new investigation also involves experts from the Wellcome Trust/Cancer Research UK Gurdon Institute and the Cambridge Institute for Medical Research. Researchers from GlaxoSmithKline (GSK) and Cellzome AG also contributed to the research, funded by Cancer Research UK.

Together, the investigators determined that the BET family of proteins responsible for leading the fusion protein with a target gene that causes leukemia. BET molecules recognize specific chemical part in the formation of DNA called chromatin.

GSK made chemical compounds developed from I-BET151; this compound has been shown to divert attention from BET protein, thereby preventing them to provide fusion proteins to target them early.

Experts say this method has been used exclusively in mouse models and in human cancer cell cultures in the laboratory. So far, the research approach is proven to work, so the team hopes to soon conduct clinical trials.

Our work shows that depend on the type of leukemia in which MLL protein capable of binding to chromatin through BET, said Professor Tony Kouzarides, deputy director of the Wellcome Trust/Cancer Research UK Gurdon Institute.

This is an 'epigenetic', the approach used for targeted therapy with chromatin DNA. This approach is exciting new avenues for drug discovery which we hope will be useful for cancer types other than MLL leukemia, he added.

MLL is very difficult to treat leukemia and the only option for patients who are resistant to standard leukemia treatment is bone marrow transplantation. We hope these findings will mean in future to healing by using this procedure to the children, explains Dr Brian Huntly from the University of Cambridge Institute for Medical Research.

Tonsils Removal with Radio Frequency

Health-Net: Symptoms of tonsillitis often appear to attack the children. The operation became a last resort to overcome them. However, there is now new ways tonsillectomy, tonsils removal with radio frequency.

Tonsils or tonsillitis is a part of the lymph nodes are located on the right-left larynx.

Although it can be suffered by anyone, most of the more experienced of the tonsils and adenoids of children aged five to 15 years.

The emergence of this disease is quite disturbing patients, such as in children, which is annoying behavior, snoring during sleep, until heart failure. In addition, the symptoms of this disease in the form of throat felt dry, pain on swallowing, fever, sometimes followed by flu, colds, headaches, bad breath, nausea, and enlarged lymph nodes around the neck.

Handling inflammation of the tonsils is very diverse. Start medicine therapy to raise tonsillitis tonsil removal as the final solution, he said in the event themed. Radio Frequency for Tonsillectomy, the modern handling of tonsils diseases.

The method of overcoming the past to overcome inflammation of the tonsils, that is through surgical removal of tonsils. Operations to be one way for the case with tonsil infected and the growing size so that disrupt road and street respiratory eat. When the tonsils become a den of germs, the infection often recurs. Tonsillectomy is the most frequently performed surgery ENT specialist doctor.

In the United States in 1985 reported an average of 350-400 thousand performs tonsillectomy.

Currently, operations are supported by cutting-edge technologies and devices that reduce risk and so relieve the effects for the patient.

Since the last decade, introduced a new way of using advanced technology in the surgical tonsils removal, which is using radio frequency techniques. The radio frequency energy is a device that uses low temperatures (40-70 degrees Celsius), in contrast to electrocute technique that uses energy to the temperature reached 400 degrees Celsius.

Radio frequency using radio waves at frequencies from 1.5 to 4.5 MHz. The radio waves generated by the generator units will be streamed to the electrodes in contact with the organ to be operated. Radio energy will break the chemical bonds in the network, and ultimately result in cutting and freezing of tissue. Because this process occurs at low temperature, around the damaged tissue will be minimal.

The category of chronic tonsillitis patients to undergo surgery using radio frequency that provides the comfort level far above the conventional surgical procedure, even with a faster recovery process.

Based on research conducted in several countries, concluded that the use of radio frequencies in the tonsillectomy (tonsils removal) has several advantages, including shorter duration of surgery, less bleeding, and postoperative pain that is lighter because there is not an open surgical wound.

Using radio frequency technology to tonsils removed is not only used for tonsillectomy. Radio frequencies can also be used for operations to address other issues surrounding the ear nose throat, including snoring and nose the enlarged (hypertrophy), which resulted in blockage of the nose.

Medicine Will Work More Effectively if swallowed with Sugar

Health-Net: There are some people who require sugar to help swallow the bitter medicine. And the researchers found that sugar not only helps swallow the medicine, but also make the work medicine such as antibiotics become more effective.

Researchers found that antibiotics are taken together with a spoonful of sugar can dramatically increase the effectiveness against a stubborn infections like tuberculosis.

Laboratory tests showed that glucose and fructose (a type of sugar found in plants) can stimulate the bacteria and make it more potent against the medicine.

If the old term 'spoonful of sugar make the medicine go down easier (easier to swallow) then the new term' spoonful of sugar make the medicine work ', explained Professor James Collins, of Boston University, as reported by the Telegraph.

According to Professor Collins, chronic and recurrent infections often occur when the bacteria off and become metabolically active. Over the past few weeks or months, the bacteria will come back to life, become stronger and more aggressive than before, thus making the disease the patient relapsed.

Germs are persistent are different from bacteria that develop resistance (immunity) of antibiotics through genetic mutations, but the persistent bacteria can cause many problems.

And the scientists look for new ways to cope with the persistent bacteria rose from hibernation by using a simple weapon, namely sugar.

Scientists found that the sugar acts as a stimulant that is active against bacteria and make the normal response of bacteria vulnerable to antibiotics.

The study was then performed by testing Escherichia coli (E. coli), which is a common cause of urinary tract infections.

As a result, researchers were able to eliminate 99.9 percent of persister (persistent bacteria) in just two hours. Without sugar, the drugs used have no effect.

The study reported in the journal Nature also shows that the approach is as effective against persistent bacteria Staphylococcus aureus, which can produce serious infections.

Prof. Collins is now planning to investigate whether the addition of sugar to enhance the effectiveness of drugs against tuberculosis.